|
Epstein-Barr Virus Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Epstein-Barr virus (EBV) infection was significantly more common in SAP-deficient 10/13 (76.9%) than XIAP-deficient 2/7 (28.6%) patients, as was hypogammaglobulinemia (10/13 (76.9%) vs. 1/7 (14.3%)).
|
31754776 |
2020 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HSCT is the only curative therapy for XLP and this therapy should be urgently considered.What is Known:• SAP and XIAP deficiencies share common clinical feature, HLH, whereas they also have their own specific manifestations.• IBD affects 25-30% of XIAP-deficient patients, which has been reported in other countries especially in European country and Japan.What is New:• This is the largest patient cohort study of XLP in China.• We firstly summarized the clinical features and outcomes of Chinese XIAP-deficient patients and found only 1 in 22 patients developed IBD and diet background may contribute to it; Asian SAP-deficient patients carrying SH2D1A R55X mutation were more prone to HLH.
|
31754776 |
2020 |
|
Lymphoproliferative Syndrome, X-Linked, 2
|
0.050 |
Biomarker
|
disease |
BEFREE |
We identified 13 and 7 patients with SAP and XIAP deficiency, respectively, in our center.
|
31754776 |
2020 |
|
Lymphohistiocytosis, Hemophagocytic
|
0.040 |
Biomarker
|
disease |
BEFREE |
One XIAP- and three SAP-deficient patients died, while 3/7(42.9%) and 4/13(30.8%), respectively, developed hemophagocytic lymphohistiocytosis (HLH).
|
31754776 |
2020 |
|
Hypogammaglobulinemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Significantly reduced levels of switched memory B cells were observed in six SAP-deficient patients with persistent hypogammaglobulinemia.
|
31754776 |
2020 |
|
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the SAP-drug group had better efficacy on promoting tubular cell proliferation and dedifferentiation than SAP or Free-drug alone, and thus reduced chronic renal fibrosis in I/R mice.
|
31843715 |
2020 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the SAP-drug group had better efficacy on promoting tubular cell proliferation and dedifferentiation than SAP or Free-drug alone, and thus reduced chronic renal fibrosis in I/R mice.
|
31843715 |
2020 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reduced XRCC6 activity and function may be relevant to ASD etiology due to XRCC6's role in nonhomologous DNA repair and interactions of the C-terminal SAP domain with DEAF1, a nuclear transcriptional regulator that is important during embryonic development.
|
31827253 |
2020 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Defective signaling via 2B4 due to mutations in signaling adaptor SAP contributes to X-linked lymphoproliferative Disease (XLP).
|
30347240 |
2019 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, SAP deficiency causes X-linked lymphoproliferative disease with multiple immune defects including a lack of circulating NKT cells.
|
31293596 |
2019 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In human patients with X-linked lymphoproliferative (XLP) disease, which is caused by SAP mutations, SFRs alternatively bind other inhibitory SH2 domain-containing molecules to suppress immune cell activation and development.
|
30911116 |
2019 |
|
Stable angina
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Groups were divided as follows: normal coronary artery (control group), nonobstructive coronary atherosclerosis (<50% stenosis in all coronary vessels, NOCA group), stable angina (SAP group), and acute coronary syndrome (ACS group).
|
31275446 |
2019 |
|
Stable angina
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The patients were divided in 4 groups: patients without coronary artery disease (control group), patients with stable angina pectoris (SAP group), patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS group), and patients with ST-segment elevation acute myocardial infarction group (STEMI group).
|
30898992 |
2019 |
|
Acute pancreatitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate whether early (first 48 h) hyperchloremia and/or the change of serum chloride concentration are associated with acute kidney injury (AKI) in patients with moderately severe and severe acute pancreatitis (MSAP and SAP).
|
30473463 |
2019 |
|
Acute pancreatitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Amelioration of both experimental AP and SAP by CB0313.1 indicated a non-model-specific effect.
|
31034143 |
2019 |
|
ST segment elevation myocardial infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
RESULTS Our results found the protein levels of Syk and inflammatory factors expression in the NSTE-ACS and STEMI groups were higher than those in the SAP and control groups.
|
30898992 |
2019 |
|
ST segment elevation myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Patients with STEMI (20 ND, 13 T2D) and 3 control groups (non-STEMI [14 ND, 13 T2D], stable angina pectoris [SAP] [8 ND, 10 T2D] patients and healthy subjects) (n = 25) were studied.
|
30084185 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i>-differentiated human CD163<sup>+</sup> and CD204<sup>+</sup> macrophages both secreted TGF-β1; however, the novel IPF drug pentraxin 2/serum amyloid protein could suppress secretion only by CD204<sup>+</sup> macrophages.
|
31656675 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: an open-label extension study.
|
31122893 |
2019 |
|
Virus Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Although high APP levels have been broadly associated with bacterial infections, there is a growing body of evidence revealing increased PTX, CRP and SAP expression upon viral infection.
|
31323216 |
2019 |
|
Gestational Diabetes
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Three proteins; afamin, serum amyloid P-component and vitronectin could be further confirmed as predictors of GDM in a validation set.
|
30917176 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We aimed to evaluate whether early (first 48 h) hyperchloremia and/or the change of serum chloride concentration are associated with acute kidney injury (AKI) in patients with moderately severe and severe acute pancreatitis (MSAP and SAP).
|
30473463 |
2019 |
|
Delirium, Dementia, Amnestic, Cognitive Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, the CATB/SAPC complex represents a novel target against HIV-associated neurocognitive disorders.
|
31142756 |
2019 |
|
Uveitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A three-analyte biosignature (Apo-A1, SAP and CRP) separated the herpetic group from other groups with AUC = 0.79 (95% CI: 0.65-0.93).<i>Conclusion</i>: We have identified candidate biomarkers with potential to differentiate between herpetic, syphilitic and other causes of uveitis.
|
31697216 |
2019 |
|
Hyperchloremia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate whether early (first 48 h) hyperchloremia and/or the change of serum chloride concentration are associated with acute kidney injury (AKI) in patients with moderately severe and severe acute pancreatitis (MSAP and SAP).
|
30473463 |
2019 |